When dealing with DB's I think it's best to use the one facing the less elite QB.  The only other issue is picking the correct DB to go off against the opposing QB.  In this case, with Roach filling in at LB for Pisa Tinoisamoa out with injury, Wallace may go to the right side a lot, which should allow a great game for C.Tillman…. I can't believe there is any science to determining which DB will outperform everyone else other than going with the winning teams defensive backs.  Starting Payne over D.Manning doesn't really make sense though unless I'm missing something here.  I'd go with Wilson.